Hence, the model can effectively be applied to determine how consumption of an HF diet modifies the negative feedback system that controls body fat.
Antioxid Redox Signal 8 9— J Altern Complement Med 8: High-fat diet-induced obesity Rat model: Male Wistar rats were randomly divided into four groups, namely, the normal control NC which received standard rodent diet, the high fat diet HFD which received high fat diet only, the high fat diet treated with T.
Duration of diet regimen in weeks W before STZ treatment. Induction of Insulin Resistance After acclimatization high-fat diet wistar rats one week, animals were randomly divided into four different groups namely, the normal control NC which received standard rodent diet, the high fat diet HFD which received high fat diet only, the high fat diet treated with T.
Hasan, H. In general, the mechanism of action of orlistat is by facilitating the decrease in the absorption of fat in gastrointestinal tract, thus preventing excessive fat deposition in the body.
Furthermore, in the majority of the published reports considering the effects of HF diets, only one or a few dependent variables were considered, and there has been little continuity either between or over time from the same laboratory group.
As in the case of prediabetes, type 2 diabetes is also intimately related to dyslipidemia 33 and hepatic steatosis 47as well as with hypoadiponectinemia 48 and increased levels of the liver damage marker alanine aminotransferase Arterioscler Thromb Vasc Biol 23 3: However, the cellular and molecular mechanism s underlying these basic defects is not clear yet.
Methods 2. Gross necropsy findings did not reveal changes in any of the organs examined Figure 1. Table 7: The other half of the tissue was rapidly washed with warm phosphate buffer pH 7.
However, the majority of these effects were more pronounced or earlier detected in Wistar rats. The model was concluded be mimic the early stage if glucose and insulin levels were higher than in controls, whereas the model was concluded to mimic the late stage if insulin levels were lower than or the same as in controls.
These results suggest that long-term consumption of T. The hepatocytes were also neatly arranged with the sinusoids radiating from the central vein Figure 1 c. Physiol Res 59 4: Am J Clin Nutr 72 4: Ruan, P. Table 2: Although the etiology of obesity is complex, dietary factors, particularly the consumption of a high-fat HF diet, is considered a risk factor for its development.
This article has been cited by other articles in PMC. The uncontrolled phenomenon can lead to metabolic diseases such as hypertension, heart disease, and cancer [ 3 ].7/7/ · Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver Female Wistar rats were fed on Cited by: 2/21/ · Understanding of nonalcoholic steatohepatitis (NASH) is hampered by the lack of a suitable model.
Our aim was to investigate whether long term high saturated-fat feeding would induce NASH in rats. 21 day-old rats fed high fat diets for 14 weeks, with either coconut oil or butter, and were compared with rats feeding a standard diet or a methionine choline-deficient (MCD) diet, a non Cited by: 12/1/ · Male Wistar rats were randomly divided into four groups, namely, the normal control (NC) which received standard rodent diet, the high fat diet (HFD) which received high fat diet only, the high fat diet treated with T.
crispa (HFDTC), and the high fat diet treated with orlistat (HFDO). After sixteen weeks of treatment, blood and organs were Cited by: 4. Materials and methods. In the present study chronic administration of sitagliptin (10, 20 and 40 mcg/kg/day p.o) for 6 weeks along with high fat diet to the obese rats which were pretreated with high fat diet feeding for 4 weeks on the various parameters of obesity were analyzed.
2/25/ · Methods.
High-fat diet (HFD), high-fructose beverages (HF) or both (HFHF) were compared to rats fed with normal diet (ND) for 8 months to induce.
5/19/ · In order to further elucidate the pathobiology of this disease, animal models mimicking the pathology of human type 2 diabetes are of great value. One example of a type 2 diabetes animal model is the high‐fat diet‐fed, streptozotocin (HFD/STZ)‐treated rat festival-decazeville.com by: